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Thesis

Kinetic investigations of the oxygen entry pathway of the hypoxia-inducible factor (HIF) prolyl hydroxylase 2

Abstract:

Human hypoxia inducible factor (HIF) is responsible for mediating the body’s response to low O2 availability. The levels and activity of HIF are regulated by four Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases, prolyl-hydroxylase domains 1-3 (PHD 1-3) and factor-inhibiting HIF (FIH), collectively termed the HIF hydroxylases. The PHDs catalyse hydroxylation of specific prolyl residues in the N - and C - terminal oxygen-dependent degradation domains of HIF-α, targeting it for de...

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Institution:
University of Oxford
Oxford college:
Hertford College
Role:
Author

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Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
UUID:
uuid:0071cd6c-609a-483f-89b1-652e09bc9370
Deposit date:
2016-06-17

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