Journal article icon

Journal article

Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons.

Abstract:

The firing of hypothalamic hypocretin/orexin neurons is vital for normal sleep-wake transitions, but its molecular determinants are not well understood. It was recently proposed that TASK (TWIK-related acid-sensitive potassium) channels [TASK1 (K(2P)3.1) and/or TASK3 (K(2P)9.1)] regulate neuronal firing and may contribute to the specialized responses of orexin neurons to glucose and pH. Here we tested these theories by performing patch-clamp recordings from orexin neurons directly identified ...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
European journal of neuroscience
Volume:
30
Issue:
1
Pages:
57-64
Publication date:
2009-07-01
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
Source identifiers:
314775

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP