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Using phylogeny to improve genome-wide distant homology recognition

Abstract:

The gap between the number of known protein sequences and structures continues to widen, particularly as a result of sequencing projects for entire genomes. Recently there have been many attempts to generate structural assignments to all genes on sets of completed genomes using fold-recognition methods. We developed a method that detects false positives made by these genome-wide structural assignment experiments by identifying isolated occurrences. The method was tested using two sets of assi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
Oxford Protein Informatics Group
Department:
Mathematical,Physical & Life Sciences Division - Statistics
Role:
Author
Engineering and Physical Sciences Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Computational Biology Journal website
Volume:
3
Issue:
1
Pages:
Article: e3
Publication date:
2007-01-05
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
URN:
uuid:00e41229-1c9f-4c1d-ac3a-b51d34bbbe8f
Local pid:
ora:1810

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