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Humanization of immunodeficient animals for the modeling of transplantation, graft versus host disease and regenerative medicine

Abstract:

The humanization of animals is a powerful tool for the exploration of human disease pathogenesis in biomedical research, as well as for the development of therapeutic interventions with enhanced translational potential. Humanized models enable us to overcome biological differences that exist between humans and other species, whilst giving us a platform to study human processes in vivo. To become humanized, an immune deficient recipient is engrafted with cells, tissues or organoids. The mouse ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1097/tp.0000000000003177

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Sub department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Sub department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Sub department:
Surgical Sciences
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0002-8279-7732
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Grant:
105605/Z/14/Z
204826/Z/16/Z
211122/Z/18/Z
Publisher:
Lippincott, Williams and Wilkins Publisher's website
Journal:
Transplantation Journal website
Volume:
104
Issue:
11
Pages:
2290-2306
Publication date:
2020-02-14
Acceptance date:
2020-01-07
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
Pmid:
32068660
Language:
English
Keywords:
Pubs id:
1089297
Local pid:
pubs:1089297
Deposit date:
2020-03-11

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