Thesis
The safety, tolerability and biochemical efficacy of extended release niacin and laropiprant in a major randomised clinical trial
- Abstract:
-
Niacin has been in clinical use for over 50 years and was the first drug shown in a randomized trial to improve outcomes after MI, but substantial uncertainty remains about its efficacy and safety in the context of current standard medical therapy.
This thesis explores the biochemical efficacy, tolerability and safety of extended release (ER) niacin/laropiprant in the large, randomized HPS2-THRIVE trial. Laropiprant is a prostaglandin D₂ receptor (DP1) antagonist which reduces the ma...
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Authors
Contributors
+ Armitage, J
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DM
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:01ba360a-fe6a-4a1a-ba14-48a2dcc3e0dd
- Local pid:
- ora:8768
- Deposit date:
- 2014-07-11
Terms of use
- Copyright holder:
- Haynes, R
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available via ORA.
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