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Opioid-independent and opioid-mediated modes of pain modulation

Abstract:

Pain is regulated endogenously through both opioid and non-opioid mechanisms. We hypothesized that two novel pain modulation tasks, one drawing on context/expectations and one using voluntary reappraisal, would show differing levels of opioid dependence. Specifically, we expected that naloxone would block context-related analgesia, whereas mental imagery-based pain reappraisal would be opioid-independent.

A double-blind, placebo-controlled intravenous naloxone versus saline crossov...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1523/jneurosci.0854-18.2018

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Oxford college:
Merton College
Role:
Author
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Funding agency for:
Goodwin, G
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Funding agency for:
Tracey, I
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Publisher:
Society for Neuroscience Publisher's website
Journal:
Journal of Neuroscience Journal website
Volume:
38
Issue:
42
Pages:
9047-9058
Publication date:
2018-10-17
Acceptance date:
2018-08-14
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Pmid:
30201765
Source identifiers:
920937
Language:
English
Keywords:
Pubs id:
pubs:920937
UUID:
uuid:01d19c02-6c33-47a8-817b-dbd258da1d61
Local pid:
pubs:920937
Deposit date:
2018-10-26

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