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Journal article

MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

Abstract:

MLP (muscle LIM protein)-deficient mice count among the first mouse models for dilated cardiomyopathy (DCM), yet the exact role of MLP in cardiac signalling processes is still enigmatic. Elevated PKCasignalling activity is known to be an important contributor to heart failure. Here we show that MLP directly inhibits the activity of PKCa. In end-stage DCM, PKCa is concentrated at the intercalated disc of cardiomyocytes, where it is sequestered by the adaptor protein CARP in a multiprotein comp...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms12120

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Funding agency for:
Gehmlich, K
Grant:
FS/12/40/29712
National Heart, Lung, and Blood Institute More from this funder
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Publisher:
Nature Publishing Group: Nature Communications Publisher's website
Journal:
Nature Communications Journal website
Volume:
7
Pages:
12120
Publication date:
2016-06-01
Acceptance date:
2016-05-31
DOI:
ISSN:
2041-1723
Source identifiers:
630613
Pubs id:
pubs:630613
UUID:
uuid:0242b30c-7bc1-44d2-8dc7-bcea7a2581b4
Local pid:
pubs:630613
Deposit date:
2016-06-29

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