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Journal article

Discovery and characterization of ZUFSP/ZUP1, a distinct deubiquitinase class important for genome stability

Abstract:

Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. Here, we report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal structures of ZUFSP in complex with ubiquitin reveal several distinctive features of ubiquitin recognition and catalysis. Our analyses reveal that ZUFSP is a novel DUB with no homology to any known DUBs, leading us to classify ZUFSP as the seventh DUB family. Intriguingly, the min...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.molcel.2018.02.023

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Publisher:
Elsevier Publisher's website
Journal:
Molecular Cell Journal website
Volume:
70
Issue:
1
Pages:
150-164.e6
Publication date:
2018-03-22
Acceptance date:
2018-02-15
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Pmid:
29576527
Source identifiers:
833761
Language:
English
Keywords:
Pubs id:
pubs:833761
UUID:
uuid:024b479e-8954-4019-9dc6-836f56d052c1
Local pid:
pubs:833761
Deposit date:
2019-07-01

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