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Allostatic load as a predictor of grey matter volume and white matter integrity in old age: The Whitehall II MRI study

Abstract:

The allostatic load index quantifies the cumulative multisystem physiological response to chronic everyday stress, and includes cardiovascular, metabolic and inflammatory measures. Despite its central role in the stress response, research of the effect of allostatic on the ageing brain has been limited. We investigated the relation of mid-life allostatic load index and multifactorial predictors of stroke (Framingham stroke risk) and diabetes (metabolic syndrome) with voxelwise structural grey...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-018-24398-9

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
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Funding agency for:
Singh-Manoux, A
Grant:
R01AG034454
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Funding agency for:
Kivimäki, M
Grant:
K013351
More from this funder
Funding agency for:
Kivimäki, M
Grant:
K013351
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Article number:
6411
Publication date:
2018-04-23
Acceptance date:
2018-03-26
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Source identifiers:
831764
Pubs id:
pubs:831764
UUID:
uuid:024b7108-3782-4973-a18b-4fcb59e884e2
Local pid:
pubs:831764
Deposit date:
2018-03-26

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