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Lipid-dependent regulation of ion channels and GPCRs: insights from structures and simulations

Abstract:

Ion channels and GPCRs are regulated by lipids in their membrane environment. Structural studies combined with biophysical and molecular simulation investigations reveal interaction sites for specific lipids on membrane protein structures. For K channels, PIP2 plays a key role in regulation of Kv and Kir channels. Likewise, a number of recent cryo-EM structures of TRP channels have revealed bound lipids, including PIP2 and cholesterol. Amongst the pentameric ligand-gated ion channel (pLGIC) f...

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Publication status:
Published
Peer review status:
Peer reviewed

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Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Christ Church
Role:
Author
ORCID:
0000-0001-6360-7959
Publisher:
Annual Reviews Publisher's website
Journal:
Annual Review of Pharmacology and Toxicology Journal website
Volume:
60
Pages:
31-50
Publication date:
2019-09-10
Acceptance date:
2019-04-11
DOI:
ISSN:
0362-1642
Source identifiers:
1002865
Language:
English
Keywords:
Pubs id:
1002865
UUID:
uuid:02734590-44f8-48f2-b4b6-617e53fc38cf
Local pid:
pubs:1002865
Deposit date:
2019-05-23

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