Journal article
Common coding variant in SERPINA1 increases the risk for large artery stroke
- Abstract:
-
Large artery atherosclerotic stroke (LAS) shows substantial heritability not explained by previous genome-wide association studies. Here, we explore the role of coding variation in LAS by analyzing variants on the HumanExome BeadChip in a total of 3,127 cases and 9,778 controls from Europe, Australia, and South Asia. We report on a nonsynonymous single-nucleotide variant in serpin family A member 1 (SERPINA1) encoding alpha-1 antitrypsin [AAT; p.V213A; P = 5.99E-9, odds ratio (OR) = 1.22] and...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Medical Research Council
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Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 114
- Issue:
- 14
- Pages:
- 3613-3618
- Publication date:
- 2017-03-06
- Acceptance date:
- 2017-02-08
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Pmid:
-
28265093
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:685636
- UUID:
-
uuid:027bcd05-7637-4dc5-9a48-467ebd4f9e0a
- Local pid:
- pubs:685636
- Source identifiers:
-
685636
- Deposit date:
- 2019-01-11
Terms of use
- Copyright holder:
- Malik et al
- Copyright date:
- 2017
- Notes:
- Freely available online through the PNAS open access option.
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