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Thesis

Radical chemistry for selective modification of native residues in proteins

Abstract:

The chemical modification of proteins has provided a toolbox enabling many experiments in chemical biology. However, new strategies are required to be able to specifically target (hetero)aromatic residues. Fluorine atoms installed in proteins can serve as useful tags, but methods for efficient and selective chemical fluorination are limited. This thesis has explored the modification of native residues in proteins with fluoroalkyl radicals to address the shortage in current methodologies. ...

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Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0001-8638-5308
Role:
Supervisor
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Programme:
ISOTOPICS - Marie Skłodowska-Curie grant agreement No. 675071
Grant:
675071
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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