Thesis
Radical chemistry for selective modification of native residues in proteins
- Abstract:
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The chemical modification of proteins has provided a toolbox enabling many experiments in chemical biology. However, new strategies are required to be able to specifically target (hetero)aromatic residues. Fluorine atoms installed in proteins can serve as useful tags, but methods for efficient and selective chemical fluorination are limited. This thesis has explored the modification of native residues in proteins with fluoroalkyl radicals to address the shortage in current methodologies. ...
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Authors
Contributors
+ Gouverneur, V
Role:
Supervisor
ORCID:
0000-0001-8638-5308
+ Davis, B
Role:
Supervisor
Funding
+ Horizon 2020
More from this funder
Programme:
ISOTOPICS - Marie Skłodowska-Curie grant agreement No. 675071
Grant:
675071
Funder identifier:
http://dx.doi.org/10.13039/501100007601
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2021-01-21
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Terms of use
- Copyright holder:
- Imiolek, M
- Copyright date:
- 2020
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