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The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis.

Abstract:

Secretion of Wnts by adipose cells has an important role in the control of murine adipogenesis. We present the first evidence that a Wnt antagonist, Dickkopf 1 (Dkk1), is secreted by human preadipocytes and promotes adipogenesis. DKK1 mRNA increases six hours after onset of human adipogenesis and this is followed by an increase in Dkk1 protein. With further differentiation, the mRNA and protein levels progressively decline such that they are undetectable in mature adipocytes. The transient in...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.02975

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Journal:
Journal of cell science
Volume:
119
Issue:
Pt 12
Pages:
2613-2620
Publication date:
2006-06-01
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
Source identifiers:
149976

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