Journal article
The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis.
- Abstract:
-
Secretion of Wnts by adipose cells has an important role in the control of murine adipogenesis. We present the first evidence that a Wnt antagonist, Dickkopf 1 (Dkk1), is secreted by human preadipocytes and promotes adipogenesis. DKK1 mRNA increases six hours after onset of human adipogenesis and this is followed by an increase in Dkk1 protein. With further differentiation, the mRNA and protein levels progressively decline such that they are undetectable in mature adipocytes. The transient in...
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- Publication status:
- Published
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- Publisher copy:
- 10.1242/jcs.02975
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Authors
Bibliographic Details
- Journal:
- Journal of cell science
- Volume:
- 119
- Issue:
- Pt 12
- Pages:
- 2613-2620
- Publication date:
- 2006-06-01
- DOI:
- EISSN:
-
1477-9137
- ISSN:
-
0021-9533
- Source identifiers:
-
149976
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:149976
- UUID:
-
uuid:02ef70d3-af63-45e0-b7b6-7ebabee983e6
- Local pid:
- pubs:149976
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2006
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