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MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes.

Abstract:

Prion diseases are fatal chronic neurodegenerative diseases. Previous qualitative magnetic resonance imaging (MRI) and spectroscopy (MRS) studies report conflicting results in the symptomatic stages of the disease, but little work has been carried out during the earlier stages of the disease. Here we have used the murine ME7 model of prion disease to quantitatively investigate MRI and MRS changes during the period prior to the onset of overt clinical signs (20+ weeks) and have correlated thes...

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Publication status:
Published

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Publisher copy:
10.1016/j.nbd.2007.04.001

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Neurobiology of disease
Volume:
26
Issue:
3
Pages:
707-717
Publication date:
2007-06-01
DOI:
EISSN:
1095-953X
ISSN:
0969-9961
Source identifiers:
131177

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