Journal article
Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis.
- Abstract:
-
Chemokines (CK) provide directional cues that mediate the recruitment of leukocytes to sites of inflammation. Broad-spectrum blockade of the CC-CK family, using the vaccinia virus 35K protein, has been shown to cause a potent reduction of systemic inflammation in models of atherosclerosis, vein graft disease and arthritis. We have used a cell membrane-targeted form of 35K, Mem35K, to probe whether cell-associated blockade of chemokine response is sufficient to reduce cell recruitment in infla...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
National Institute for Health
Research Oxford Biomedical Research Centre
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Wellcome Trust
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British Heart Foundation
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Bibliographic Details
- Publisher:
- Springer Berlin Heidelberg Publisher's website
- Journal:
- Journal of molecular medicine (Berlin, Germany) Journal website
- Volume:
- 92
- Issue:
- 11
- Pages:
- 1169-1178
- Publication date:
- 2014-11-01
- DOI:
- EISSN:
-
1432-1440
- ISSN:
-
0946-2716
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:478427
- UUID:
-
uuid:03a0211b-33f1-4404-b863-510c85fadcc7
- Local pid:
- pubs:478427
- Source identifiers:
-
478427
- Deposit date:
- 2014-08-15
Terms of use
- Copyright holder:
- McNeill et al
- Copyright date:
- 2014
- Notes:
-
Copyright © The Author(s) 2014. This article is distributed under the terms of the Creative
Commons Attribution License which permits any use, distribution, and
reproduction in any medium, provided the original author(s) and the
source are credited.
- Licence:
- CC Attribution (CC BY)
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