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Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles

Abstract:

Although host genetics influences susceptibility to tuberculosis (TB), few genes determining disease outcome have been identified. We hypothesized that macrophages from individuals with different clinical manifestations of Mycobacterium tuberculosis (Mtb) infection would have distinct gene expression profiles and that polymorphisms in these genes may also be associated with susceptibility to TB. We measured gene expression levels of >38,500 genes from ex vivo Mtb...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1000229

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Vietnam/OUCRU
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Vietnam/OUCRU
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Vietnam/OUCRU
Role:
Author
More from this funder
Funding agency for:
Farrar, J
More from this funder
Funding agency for:
Dunstan, S
Farrar, J
Hawn, T
Publisher:
PLoS Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
4
Issue:
12
Article number:
e1000229
Publication date:
2008-12-05
Acceptance date:
2008-11-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pmid:
19057661
Source identifiers:
92797
Keywords:
Pubs id:
pubs:92797
UUID:
uuid:0426f081-e8e7-4eba-be60-c570ee245422
Local pid:
pubs:92797
Deposit date:
2017-05-03

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