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Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Abstract:

Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 × 10-8) with PrCa and one locus significantly associated with early-on...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41588-018-0142-8

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Role:
Author
ORCID:
0000-0002-3073-7463
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Publisher:
Nature Research Publisher's website
Journal:
Nature genetics Journal website
Volume:
50
Pages:
928-936
Publication date:
2018-06-11
Acceptance date:
2018-04-05
DOI:
ISSN:
1061-4036 and 1546-1718
Pmid:
29892016
Source identifiers:
857087
Language:
English
Keywords:
Pubs id:
pubs:857087
UUID:
uuid:054475a9-be61-4951-bb9e-e391e202e0a4
Local pid:
pubs:857087
Deposit date:
2019-02-28

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