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Identifying chondrogenesis strategies for tissue engineering of articular cartilage

Abstract:

A key step in the tissue engineering of articular cartilage is the chondrogenic differentiation of mesenchymal stem cells (MSCs) into chondrocytes (native cartilage cells). Chondrogenesis is regulated by transforming growth factor-β (TGF-β), a short-lived cytokine whose effect is prolonged by storage in the extracellular matrix. Tissue engineering applications aim to maximise the yield of differentiated MSCs. Recent experiments involve seeding a hydrogel construct with a layer of MSCs lying b...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/2041731419842431

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Computer Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Oxford college:
St Anne's College
Role:
Author
ORCID:
0000-0001-5285-0523
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Publisher:
SAGE Publications Publisher's website
Journal:
Journal of Tissue Engineering Journal website
Volume:
10
Pages:
1-14
Publication date:
2019-04-22
Acceptance date:
2019-03-14
DOI:
ISSN:
2041-7314
Source identifiers:
983332
Keywords:
Pubs id:
pubs:983332
UUID:
uuid:05606e0e-e4b9-4fff-acd1-9a2e6e393165
Local pid:
pubs:983332
Deposit date:
2019-03-18

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