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Journal article

Population pharmacokinetics and cerebrospinal fluid penetration of fluconazole in adults with cryptococcal meningitis

Abstract:

Robust population pharmacokinetic (PK) data for fluconazole are scarce. The variability of fluconazole penetration into the CNS is not known. A fluconazole PK study was conducted in 43 patients receiving oral fluconazole (usually 800 mg q24h) in combination with amphotericin B deoxycholate (1 mg/kg q24h) for cryptococcal meningitis (CM). A 4-compartment PK model was developed and Monte Carlo simulations performed for a range of fluconazole dosages. A meta-analysis of trials reporting outcomes...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.00885-18

Authors


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Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDM
Role:
Author
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United Kingdom Department for International Development More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
62
Issue:
9
Pages:
e00885-18
Publication date:
2018-06-18
Acceptance date:
2018-04-27
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pmid:
29914943
Source identifiers:
859156
Language:
English
Keywords:
Pubs id:
pubs:859156
UUID:
uuid:060b1823-ec56-402d-be69-45fd086754f8
Local pid:
pubs:859156
Deposit date:
2018-07-03

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