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Journal article

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans.

Abstract:

The 18kDa Translocator Protein (TSPO) is the most commonly used tissue-specific marker of inflammation in positron emission tomography (PET) studies. It is expressed in myeloid cells such as microglia and macrophages, and in rodent myeloid cells expression increases with cellular activation. We assessed the effect of myeloid cell activation on TSPO gene expression in both primary human and rodent microglia and macrophages in vitro, and also measured TSPO radioligand binding with 3H-PBR28 in p...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/0271678x17710182

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
Imanova Centre for Imaging Sciences More from this funder
UK Multiple Sclerosis Society More from this funder
Medical Research Council More from this funder
Publisher:
SAGE Publications Publisher's website
Journal:
Journal of Cerebral Blood Flow and Metabolism Journal website
Volume:
37
Issue:
8
Pages:
2679-2690
Publication date:
2017-05-01
Acceptance date:
2017-04-18
DOI:
ISSN:
1559-7016 and 0271-678X
Pmid:
28530125
Source identifiers:
718605

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