Journal article icon

Journal article

Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224.

Abstract:

Mirtrons are a recently described category of microRNA (miRNA) relying on splicing rather than processing by the microprocessor complex to generate pre-miRNA precursors of the RNA interference (RNAi) pathway. Their discovery and subsequent verification provides important information about a distinct class of miRNA and inherent advantages that could be exploited to silence genes of interest. These include micro-processor-independent biogenesis, pol-II-dependent transcription, accurate species ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1093/nar/gks712

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Funding agency for:
Weinberg, MS
Expand funders...
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
40
Issue:
19
Pages:
9863-9875
Publication date:
2012-10-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Source identifiers:
344196
Language:
English
Keywords:
Pubs id:
pubs:344196
UUID:
uuid:06aaa161-9e7b-43df-8b95-26a000d33636
Local pid:
pubs:344196
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP