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Recent Progress in Histone Demethylase Inhibitors

Abstract:

There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with small molecules both for the generation of probes for target exploration and for therapeutic purposes. Here we update on previous reviews on the inhibition of the lysine-specific demethylases (LSDs or KDM1s) and JmjC families of N-methyl-lysine demethylases (JmjC KDMs, KDM2-7), focusing on the academic and patent literature from 2014 to date. We also highlight recent biochemical, biological, and structu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
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Institution:
University of Oxford
Oxford college:
Corpus Christi College
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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British Heart Foundation More from this funder
Wellcome Trust More from this funder
Cancer Research UK More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of medicinal chemistry Journal website
Volume:
59
Issue:
4
Pages:
1308-1329
Publication date:
2015-12-28
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
Pmid:
26710088
Source identifiers:
3519
Language:
English
Keywords:
Pubs id:
pubs:599239
UUID:
uuid:07826c31-26ad-49b3-9d57-24e8cf161096
Local pid:
pubs:599239
Deposit date:
2017-03-07

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