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Thesis

Molecular simulations of ion channel gating

Abstract:

Ion channels are membrane proteins that facilitate ion permeation across the membrane down the concentration gradient. Recently, many structures of the ion channels were solved using cryo-electron microscopy. An advancement in structural determination and computational power has enabled ion channels to be thoroughly investigated at the molecular level using molecular dynamics (MD) simulation. Here, I used a range of methods, including coarse-grained MD, free energy perturbation (FEP) and atom...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
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Programme:
DPhil Ion channel, membrane transport and disease
Grant:
BST00130 AV02.01
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2022-06-24

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