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Thesis

Imaging of HIV-1 spread from T cells and Macrophages to Astrocytes

Abstract:

CD4+ T cells and macrophages are the principal targets of HIV-1. They can be productively infected with the virus and transfer virions to contacting bystander cells. It has been suggested that soon after initial infection, free virions and virus-bearing or infected T cells and macrophages can enter the brain, triggering a cascade of inflammatory signals and recruitment of other immune cells. Chronic inflammation and increased viral antigens in the brain lead to HIV-1 associated neuropathy....

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Quentin Sattentau
Oxford college:
Green Templeton College
Role:
Author

Contributors

Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:07ffd971-0b25-4990-8d17-001d943ebfa5
Local pid:
ora:9921
Deposit date:
2015-02-04

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