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Targeted IL‐4 therapy synergizes with dexamethasone to induce a state of tolerance by promoting Treg cells and macrophages in mice with arthritis

Abstract:

F8‐IL‐4 is a recently developed immunocytokine that delivers IL‐4 to sites of inflammation by targeting the neovasculature. We previously reported that F8‐IL‐4, in combination with dexamethasone (DXM), provides a durable therapy in mice with collagen‐induced arthritis (CIA). Therefore, the objective of this study was to identify the mechanism by which IL‐4 and DXM combination therapy provides long‐lasting disease remission. F8‐IL‐4 alone attenuated inflammation in CIA and this was associated ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/eji.201546221

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Role:
Author
ORCID:
0000-0001-5234-7370
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“Profiling Responder in Antibody Therapies” (PRIAT) More from this funder
European Union More from this funder
Philochem Zurich More from this funder
Publisher:
Wiley Publisher's website
Journal:
European Journal of Immunology Journal website
Volume:
46
Issue:
5
Pages:
1246-1257
Publication date:
2016-03-21
Acceptance date:
2016-02-27
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Pmid:
26919786
Source identifiers:
609118
Language:
English
Keywords:
Pubs id:
pubs:609118
UUID:
uuid:0839923d-143b-4793-847b-007613ec967d
Local pid:
pubs:609118
Deposit date:
2018-05-17

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