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Allele-specific methylation of type 1 diabetes susceptibility genes

Abstract:

The susceptibility to autoimmune diseases is influenced by genes encoding major histocompatibility complex (MHC) proteins. By examining the epigenetic methylation maps of cord blood samples, we found marked differences in the methylation status of CpG sites within the MHC genes (cis-metQTLs) between carriers of the type 1 diabetes risk haplotypes HLA-DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2) and HLA-DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8). These differences were found in children and adults, and we...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jaut.2017.11.008

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Role:
Author
ORCID:
0000-0001-6551-6030
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Grant:
HelmholtzZentrumMuenchen,JuvenileDiabetesResearchFoundation(17-2013-525),
iMed–theHelmholtzInitiativeonPersonalizedMedicine
Publisher:
Elsevier Publisher's website
Journal:
Journal of Autoimmunity Journal website
Volume:
89
Pages:
63-74
Publication date:
2017-12-07
Acceptance date:
2017-11-25
DOI:
EISSN:
1095-9157
ISSN:
0896-8411
Pmid:
29224923
Source identifiers:
810800
Language:
English
Keywords:
Pubs id:
pubs:810800
UUID:
uuid:08eabf05-8798-44cd-ba6d-e7faff5394bb
Local pid:
pubs:810800
Deposit date:
2018-02-23

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