Journal article icon

Journal article

GenomegaMap: Within-species genome-wide dN/dS estimation from over 10,000 genomes

Abstract:

The dN/dS ratio provides evidence of adaptation or functional constraint in protein-coding genes by quantifying the relative excess or deficit of amino acid-replacing versus silent nucleotide variation. Inexpensive sequencing promises a better understanding of parameters, such as dN/dS⁠, but analyzing very large data sets poses a major statistical challenge. Here, I introduce genomegaMap for estimating within-species genome-wide variation in dN/dS⁠, and I apply it to 3,979 genes across 10,209...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1093/molbev/msaa069

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Population Health
Role:
Author
ORCID:
0000-0002-0940-3311
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
et al.
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Expand authors...

Contributors

Role:
Contributor
NIEHS NIH HHS More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Molecular Biology and Evolution Journal website
Volume:
37
Issue:
8
Pages:
2450-2460
Place of publication:
United States
Publication date:
2020-03-13
Acceptance date:
2020-02-19
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
Pmid:
32167543
Language:
English
Keywords:
Pubs id:
1093508
Local pid:
pubs:1093508
Deposit date:
2020-07-06

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP