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Journal article

Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope.

Abstract:

HLA-B*27 exerts protective effects in hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections. While the immunological and virological features of HLA-B*27-mediated protection are not fully understood, there is growing evidence that the presentation of specific immunodominant HLA-B*27-restricted CD8+ T-cell epitopes contributes to this phenomenon in both infections. Indeed, protection can be linked to single immunodominant CD8+ T-cell epitopes and functional constraints on e...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1003042

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Institution:
University of Oxford
Role:
Author
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Deutsche Forschungsgemeinschaft More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
8
Issue:
11
Pages:
e1003042
Publication date:
2012-01-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Source identifiers:
365459
Language:
English
Keywords:
UUID:
uuid:09647e94-ed36-47b9-91c7-1d87800472a8
Local pid:
pubs:365459
Deposit date:
2013-11-17

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