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Journal article

Quantifying the limits of CAR T-cell delivery in mice and men

Abstract:

CAR (Chimeric Antigen Receptor) T cells have demonstrated clinical success for the treatment of multiple lymphomas and leukaemias, but not for various solid tumours, despite promising data from murine models. Lower effective CAR T-cell delivery rates to human solid tumours compared to haematological malignancies in humans and solid tumours in mice might partially explain these divergent outcomes. We used anatomical and physiological data for human and rodent circulatory systems to calculate t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rsif.2020.1013

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
ORCID:
0000-0002-6888-4362
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0001-8079-9358
Publisher:
Royal Society Publisher's website
Journal:
Journal of the Royal Society, Interface Journal website
Volume:
18
Issue:
176
Article number:
20201013
Publication date:
2021-03-03
Acceptance date:
2021-02-04
DOI:
EISSN:
1742-5662
ISSN:
1742-5689
Language:
English
Keywords:
Pubs id:
1161412
Local pid:
pubs:1161412
Deposit date:
2021-02-15

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