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Polymorphism in codon 17 of the CTLA-4 gene (+49 A/G) is not associated with susceptibility to rheumatoid arthritis in British Caucasians.

Abstract:

The role of the CTLA-4 antigen in the development of autoimmune diseases is well documented, with several autoimmune disorders showing association or linkage with the CTLA-4 locus. Its role in the aetiology of rheumatoid arthritis (RA) however, remains unclear, as the functional studies of the B7-CTLA-4 pathway in mouse models of RA and genetic studies in humans have given contrasting results. We have studied the single nucleotide polymorphism at position +49 (A/G) of the CTLA-4 gene, in a co...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Tissue antigens
Volume:
58
Issue:
1
Pages:
50-54
Publication date:
2001-07-01
DOI:
EISSN:
1399-0039
ISSN:
0001-2815
Source identifiers:
108470
Language:
English
Keywords:
Pubs id:
pubs:108470
UUID:
uuid:09a734b2-c8ea-42d5-808e-44f21104c038
Local pid:
pubs:108470
Deposit date:
2013-11-17

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