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Journal article

Impact of apolipoprotein(a) isoform size on lipoprotein(a) lowering in the HPS2-THRIVE study

Abstract:

Background

Genetic studies have shown lipoprotein(a) (Lp[a]) to be an important causal risk factor for coronary disease. Apolipoprotein(a) isoform size is the chief determinant of Lp(a) levels, but its impact on the benefits of therapies that lower Lp(a) remains unclear.

Methods

HPS2-THRIVE (Heart Protection Study 2–Treatment of HDL to Reduce the Incidence of Vascular Events) is a randomized trial of niacin–laropiprant versus placebo on a background of simvastatin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/CIRCGEN.117.001696

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Cancer Research UK More from this funder
More from this funder
Funding agency for:
Hopewell, J
Grant:
FS/14/55/30806
Publisher:
American Heart Association Publisher's website
Journal:
Circulation: Genomic and Precision Medicine Journal website
Volume:
11
Issue:
2
Pages:
e001696
Publication date:
2018-02-15
Acceptance date:
2017-12-01
DOI:
EISSN:
2574-8300
Pmid:
29449329
Source identifiers:
826106
Language:
English
Keywords:
Pubs id:
pubs:826106
UUID:
uuid:0a309f8a-df05-45c7-9208-1ee81cfcc6d8
Local pid:
pubs:826106
Deposit date:
2018-11-20

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