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Production of spliced peptides by the proteasome

Abstract:

CD8+ cytolytic T lymphocytes are essential players of anti-tumor immune responses. On tumors, they recognize peptides of about 8-to-10 amino acids that generally result from the degradation of cellular proteins by the proteasome. Until a decade ago, these peptides were thought to solely correspond to linear fragments of proteins that were liberated after the hydrolysis of the peptide bonds located at their extremities. However, several examples of peptides containing two fragments originally ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.molimm.2018.03.030

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
ORCID:
0000-0002-4995-3270
Belgian National Fund for Scientific Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Molecular Immunology Journal website
Volume:
113
Pages:
93-102
Publication date:
2018-04-09
Acceptance date:
2018-03-29
DOI:
EISSN:
1872-9142
ISSN:
0161-5890
Source identifiers:
844002
Language:
English
Keywords:
Pubs id:
pubs:844002
UUID:
uuid:0a44accf-db7a-4829-8593-0a11fe580e95
Local pid:
pubs:844002
Deposit date:
2018-04-25

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