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Genetic constraints and the adaptive evolution of rabies virus in nature

Abstract:

We used a molecular evolutionary approach to investigate the species adaptation of rabies virus in nature. A maximum likelihood analysis of selection pressures revealed that the nucleoprotein (N) and glycoprotein (G) genes of natural viral isolates were highly constrained, especially at nonsynonymous sites, in contrast to the higher rates of nonsynonymous evolution observed in viruses subject to laboratory passage. Positive selection was only found at a single amino acid site—position 183 in ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1006/viro.2001.1271

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
Institut Pasteur
Role:
Author
More by this author
Institution:
Institut Pasteur
Role:
Author
Royal Society More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Virology Journal website
Volume:
292
Issue:
2
Pages:
247–257
Publication date:
2002-01-01
DOI:
ISSN:
0042-6822
Language:
English
Keywords:
Subjects:
UUID:
uuid:0af5645d-84fa-437d-9543-c03354c26f9d
Local pid:
ora:10721
Deposit date:
2015-03-25

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