Journal article
Genetic constraints and the adaptive evolution of rabies virus in nature
- Abstract:
-
We used a molecular evolutionary approach to investigate the species adaptation of rabies virus in nature. A maximum likelihood analysis of selection pressures revealed that the nucleoprotein (N) and glycoprotein (G) genes of natural viral isolates were highly constrained, especially at nonsynonymous sites, in contrast to the higher rates of nonsynonymous evolution observed in viruses subject to laboratory passage. Positive selection was only found at a single amino acid site—position 183 in ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 179.6KB)
-
- Publisher copy:
- 10.1006/viro.2001.1271
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Royal Society
More from this funder
Biotechnology and Biological Sciences Research Council
More from this funder
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Virology Journal website
- Volume:
- 292
- Issue:
- 2
- Pages:
- 247–257
- Publication date:
- 2002-01-01
- DOI:
- ISSN:
-
0042-6822
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:0af5645d-84fa-437d-9543-c03354c26f9d
- Local pid:
- ora:10721
- Deposit date:
- 2015-03-25
Related Items
Terms of use
- Copyright holder:
- Elsevier Science Ltd
- Copyright date:
- 2002
- Notes:
- Copyright 2002 Elsevier B.V. All rights reserved. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://www.elsevier.com/open-access/userlicense/1.0/
- Licence:
- Other
If you are the owner of this record, you can report an update to it here: Report update to this record