Journal article
Regional heterogeneity of cellular prion protein isoforms in the mouse brain
- Abstract:
-
Prion diseases are a group of invariably fatal neurodegenerative disorders that include Creutzfeldt–Jakob disease in humans, scrapie in sheep and goats, and bovine spongiform encephalopathy in cattle. The infectious agent or prion is largely composed of an abnormal isoform (PrPSc) of a host encoded normal cellular protein (PrPc). The conversion of PrPc to PrPSc is a dynamic process and, for reasons that are not clear, the distribution of spongiform change and PrPSc deposition varies among pri...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1093/brain/awg205
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Brain Journal website
- Volume:
- 126
- Issue:
- 9
- Pages:
- 2065-2073
- Publication date:
- 2003-09-01
- Acceptance date:
- 2003-04-21
- DOI:
- EISSN:
-
1460-2156
- ISSN:
-
0006-8950
- Pmid:
-
12821516
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1222654
- Local pid:
- pubs:1222654
- Deposit date:
- 2022-07-03
Terms of use
- Copyright holder:
- Guarantors of Brain
- Copyright date:
- 2003
- Rights statement:
- © Guarantors of Brain 2003; all rights reserved
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