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Journal article

Regional heterogeneity of cellular prion protein isoforms in the mouse brain

Abstract:

Prion diseases are a group of invariably fatal neurodegenerative disorders that include Creutzfeldt–Jakob disease in humans, scrapie in sheep and goats, and bovine spongiform encephalopathy in cattle. The infectious agent or prion is largely composed of an abnormal isoform (PrPSc) of a host encoded normal cellular protein (PrPc). The conversion of PrPc to PrPSc is a dynamic process and, for reasons that are not clear, the distribution of spongiform change and PrPSc deposition varies among pri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awg205

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
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Role:
Author
ORCID:
0000-0001-8664-6918
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Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
126
Issue:
9
Pages:
2065-2073
Publication date:
2003-09-01
Acceptance date:
2003-04-21
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pmid:
12821516
Language:
English
Keywords:
Pubs id:
1222654
Local pid:
pubs:1222654
Deposit date:
2022-07-03

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