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Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A.

Abstract:

OBJECTIVES: To investigate the safety and immunogenicity of a booster BCG vaccination delivered intradermally in healthy, BCG vaccinated subjects and to compare with a previous clinical trial where BCG vaccinated subjects were boosted with a new TB vaccine, MVA85A. DESIGN: Phase I open label observational trial, in the UK. Healthy, HIV-negative, BCG vaccinated adults were recruited and vaccinated with BCG. The primary outcome was safety; the secondary outcome was cellular immune responses to...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0005934

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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
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Author
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Institution:
University of Oxford
Role:
Author
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Funding agency for:
Hill, A
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Funding agency for:
McShane, H
NIHR Oxford Biomedical Research Centre programme More from this funder
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Funding agency for:
McShane, H
University of Oxford More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
4
Issue:
6
Article number:
e5934
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
34759

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