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Guiding the folding pathway of DNA origami

Abstract:

DNA origami is a robust assembly technique that folds a single-stranded DNA template into a target structure by annealing it with hundreds of short ‘staple’ strands1,2,3,4. Its guiding design principle is that the target structure is the single most stable configuration5. The folding transition is cooperative4,6,7 and, as in the case of proteins, is governed by information encoded in the polymer sequence8,9,10,11. A typical origami folds primarily into the desired shape, but misfolded structu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nature14860

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
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Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Journal website
Volume:
525
Issue:
7567
Pages:
82–86
Publication date:
2015-08-19
Acceptance date:
2015-06-16
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Language:
English
Keywords:
UUID:
uuid:0c653a04-11ed-4123-9b9b-188bedadbc52
Deposit date:
2015-11-12

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