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Journal article

PET imaging of PARP expression using [18F]olaparib

Abstract:

PARP inhibitors are increasingly being studied as cancer drugs, as single agents or as a part of combination therapies. Imaging of PARP using a radiolabeled inhibitor has been proposed for patient selection, outcome prediction, dose optimization, genotoxic therapy evaluation, and target engagement imaging of novel PARP-targeting agents. Here, via the copper-mediated 18F-radiofluorination of aryl boronic esters, we accessed, for the first time, the 18F-radiolabeled isotopologue of the Food and...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2967/jnumed.118.213223

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
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Pancreatic Cancer UK More from this funder
Publisher:
Society of Nuclear Medicine Publisher's website
Journal:
Journal of Nuclear Medicine Journal website
Volume:
60
Issue:
4
Pages:
504-510
Publication date:
2018-11-02
Acceptance date:
2018-08-22
DOI:
EISSN:
2159-662X
ISSN:
0161-5505
Source identifiers:
912131
Pubs id:
pubs:912131
UUID:
uuid:0c81dcff-76c2-47c7-897d-9c05df3f9167
Local pid:
pubs:912131
Deposit date:
2018-10-01

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