Thesis
The biology of ELTD1/ADGRL4: a novel regulator of tumour angiogenesis
- Abstract:
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Background: Our laboratory identified ELTD1, an orphan GPCR belonging to the adhesion GPCR family (aGPCR), as a novel regulator of angiogenesis and a potential anti-cancer therapeutic target. ELTD1 is normally expressed in both endothelial cells and vascular smooth muscle cells and expression is significantly increased in the tumour vasculature. The aim of this project was to analyse ELTD1’s function in endothelial cells and its role in breast cancer.
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Authors
Contributors
+ Harris, AL
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Supervisor
+ Banham, AH
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Supervisor
+ Seiradake, E
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Examiner
+ Langenhan, T
Department:
Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Germany
Role:
Examiner
Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:0d00af0a-bb43-44bc-ba0b-1f8acbe34bc5
- Deposit date:
- 2018-05-18
Terms of use
- Copyright holder:
- Favara, DM
- Copyright date:
- 2017
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