Journal article
Inefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivo
- Abstract:
-
Understanding the role of cytotoxic T lymphocytes (CTLs) in controlling HIV-1 infection is vital for vaccine design. However, it is difficult to assess the importance of CTLs in natural infection. Different human leukocyte antigen (HLA) class I alleles are associated with different rates of progression to AIDS, indicating that CTLs play a protective role. Yet virus clearance rates following antiretroviral therapy are not impaired in individuals with advanced HIV disease, suggesting that weake...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 324.1KB)
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(Version of record, doc, 66.0KB)
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- Publisher copy:
- 10.1371/journal.pbio.0040090
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Authors
Funding
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Biology Journal website
- Volume:
- 4
- Issue:
- 4
- Article number:
- e90
- Publication date:
- 2006-04-01
- DOI:
- EISSN:
-
1545-7885
- ISSN:
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1544-9173
Item Description
- Language:
- English
- Subjects:
- UUID:
-
uuid:0d23c811-44a5-4e8f-8dde-4538d01a5fcc
- Local pid:
- ora:2838
- Deposit date:
- 2009-06-15
Related Items
Terms of use
- Copyright holder:
- Asquith et al
- Copyright date:
- 2006
- Notes:
- Citation: Asquith, B. et al. (2006). 'Inefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivo', PLoS Biology 4(4), e90. [Available at http://www.plosbiology.org/home.action]. © 2006 Asquith et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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