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Journal article

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis

Abstract:

The structure of the human major histocompatability (MHC) class I molecule HLA-A*0301 (HLA-A3) in complex with a nonameric peptide (KLIETYFSK) has been determined by X-ray crystallography to 2.7 Å resolution. HLA-A3 is a predisposing allele for multiple sclerosis (MS), an autoimmune disease of the central nervous system. The KLIETYFSK peptide is a naturally processed epitope of proteolipid protein, a myelin protein and candidate target for immune-mediated myelin destruction in MS. Comparison ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1107/S0907444911007888

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Research group:
Medical Research Council Human Immunology Unit
Role:
Author
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Institution:
University of Oxford
Research group:
Medical Research Council Human Immunology Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
Institut für Molekulare Neurobiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
Research group:
Medical Research Council Human Immunology Unit
Department:
Medical Sciences Division - Clinical Neurology
Role:
Author
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Institution:
Clinical Institute, Aarhus University Hospital, Aarhus, Denmark
Research group:
Medical Research Council Human Immunology Unit
Department:
Medical Sciences Division - Clinical Neurology
Role:
Author
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Funding agency for:
Siebold, C
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Funding agency for:
Friese, M
Grant:
DFG F1720/1-1
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Funding agency for:
Friese, M
Grant:
DFG F1720/1-1
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Publisher:
International Union of Crystallography Publisher's website
Journal:
Acta Crystallographica Section D: Biological Crystallography Journal website
Volume:
67
Issue:
5
Pages:
447-454
Publication date:
2011-05-01
DOI:
ISSN:
0907-4449
Language:
English
Keywords:
Subjects:
UUID:
uuid:0d95c179-ebf3-4b1a-9f0f-30378e81a3f8
Local pid:
ora:6002
Deposit date:
2012-01-11

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