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Efficacy and safety of statin therapy in older people: meta-analysis of individual participant data from 28 randomised controlled trials

Abstract:

Background: Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysis of data from all large statin trials to compare the effects of statin therapy at different ages.

Methods: In this meta-analysis, randomised trials of statin therapy were eligible if they aimed to recruit at least 1000 participants with a scheduled treatm...

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Publication status:
Published
Peer review status:
Peer revivewed

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Publisher copy:
10.1016/S0140-6736(18)31942-1

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Population Health
Oxford college:
St Cross College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Population Health
Role:
Author
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National Health and Medical Research Council Clinical Trials Centre More from this funder
Clinical Trial Service Unit and Epidemiological Studies Unit More from this funder
National Heart Foundation More from this funder
Medical Research Council More from this funder
British Heart Foundation More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Journal website
Volume:
393
Issue:
10170
Pages:
407-415
Publication date:
2019-02-02
Acceptance date:
2018-08-14
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Source identifiers:
921953
Pubs id:
pubs:921953
UUID:
uuid:0db1241b-e731-4aaf-9f3e-ab3596ebb670
Local pid:
pubs:921953
Deposit date:
2018-09-26

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