Journal article icon

Journal article

Post-trial follow-up methodology in large randomised controlled trials: a systematic review

Abstract:

Randomised controlled clinical trials typically have a relatively brief in-trial follow-up period which can underestimate safety signals and fail to detect long-term hazards, which may take years to appear. Extended follow-up after the scheduled closure of the trial allows detection of both persistent or enhanced beneficial effects following cessation of study treatment (i.e. a legacy effect) and the emergence of possible adverse effects (e.g. development of cancer).A systematic review was co...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1186/s13063-018-2653-0

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Clinical Trial Service Unit
Role:
Author
ORCID:
0000-0002-9708-9923
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
GLAM
Department:
Science and Medicine Subject Area
Sub department:
Health Care Libraries
Role:
Author
ORCID:
0000-0002-1142-6440
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Clinical Trial Service Unit
Role:
Author
Expand authors...
Publisher:
BioMed Central Publisher's website
Journal:
Trials Journal website
Volume:
19
Article number:
298
Publication date:
2018-05-30
Acceptance date:
2018-04-13
DOI:
ISSN:
1745-6215
Pmid:
29843774
Source identifiers:
857166
Language:
English
Keywords:
Pubs id:
pubs:857166
UUID:
uuid:0dd99505-d4f0-40fd-bf13-0fc911891ab6
Local pid:
pubs:857166
Deposit date:
2018-06-14

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP