Journal article
Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
- Abstract:
-
APC/C-mediated proteolysis of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-counteracting phosphatases PP1 and PP2A-B55, allowing wide-spread dephosphorylation of substrates. Meanwhile, continued APC/C activity promotes proteolysis of other mitotic regulators. Together, these activities orchestrate a complex series of events during mitotic exit. However, the relati...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 9
- Article number:
- e59885
- Publication date:
- 2020-09-01
- Acceptance date:
- 2020-08-31
- DOI:
- EISSN:
-
2050-084X
- Pmid:
-
32869743
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1130311
- Local pid:
- pubs:1130311
- Deposit date:
- 2021-05-20
Terms of use
- Copyright holder:
- Holder et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020, Holder et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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