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Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2

Abstract:

Because metastasis is associated with the majority of cancer-related deaths, its prevention is a clinical aspiration. Prostanoids are a large family of bioactive lipids derived from the activity of cyclooxygenase-1 (COX-1) and COX-2. Aspirin impairs the biosynthesis of all prostanoids through the irreversible inhibition of both COX isoforms. Long-term administration of aspirin leads to reduced distant metastases in murine models and clinical trials, but the COX isoform, downstream prostanoid,...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/JCI121985

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Role:
Author
ORCID:
0000-0001-9426-686X
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Volume:
130
Issue:
5
Pages:
1845-1862
Publication date:
2019-03-25
Acceptance date:
2019-02-13
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pmid:
30907747
Source identifiers:
986006
Language:
English
Keywords:
Pubs id:
pubs:986006
UUID:
uuid:0e7777f5-fa21-4a2d-9282-4c743c1fca4f
Local pid:
pubs:986006
Deposit date:
2019-06-12

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