Journal article
Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2
- Abstract:
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Because metastasis is associated with the majority of cancer-related deaths, its prevention is a clinical aspiration. Prostanoids are a large family of bioactive lipids derived from the activity of cyclooxygenase-1 (COX-1) and COX-2. Aspirin impairs the biosynthesis of all prostanoids through the irreversible inhibition of both COX isoforms. Long-term administration of aspirin leads to reduced distant metastases in murine models and clinical trials, but the COX isoform, downstream prostanoid,...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 11.4MB)
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- Publisher copy:
- 10.1172/JCI121985
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Authors
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- Journal of Clinical Investigation Journal website
- Volume:
- 130
- Issue:
- 5
- Pages:
- 1845-1862
- Publication date:
- 2019-03-25
- Acceptance date:
- 2019-02-13
- DOI:
- EISSN:
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1558-8238
- ISSN:
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0021-9738
- Pmid:
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30907747
- Source identifiers:
-
986006
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:986006
- UUID:
-
uuid:0e7777f5-fa21-4a2d-9282-4c743c1fca4f
- Local pid:
- pubs:986006
- Deposit date:
- 2019-06-12
Terms of use
- Copyright holder:
- Lucotti et al
- Copyright date:
- 2019
- Notes:
- © 2019 Lucotti et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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