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Microenvironment tumor metabolic interactions highlighted by qMSI: Application to the tryptophan-kynurenine pathway in immuno-oncology

Abstract:

Inhibition of NK and effector T-cell functions and activation of regulatory cell populations are the main immunosuppressive effects of indoleamine-2,3-dioxygenase1 (IDO1). By converting tryptophan (Trp) into kynurenine (Kyn), IDO1 is involved in the immune response homeostasis, and its dysregulated expression is described in immune-related pathologies, as tumors that hijack it to evade immune destruction. Thereby, IDO1 inhibitors are being developed to stimulate antitumor immune responses. Ex...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/2472555217712659

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
ORCID:
0000-0002-4995-3270
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Grant:
ApplicationsinImmuno-oncology(A1408004N
TumorMicroenvironment Characterization
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Grant:
ApplicationsinImmuno-oncology(A1408004N
TumorMicroenvironment Characterization
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Grant:
TumorMicroenvironment Characterization
ApplicationsinImmuno-oncology(A1408004N
Wallonia Region More from this funder
Publisher:
SAGE Publications Publisher's website
Journal:
SLAS DISCOVERY: Advancing Life Sciences R&D Journal website
Volume:
22
Issue:
10
Pages:
1182-1192
Publication date:
2017-05-30
Acceptance date:
2017-05-05
DOI:
EISSN:
2472-5560
ISSN:
2472-5552
Pmid:
28557618
Source identifiers:
809047
Language:
English
Keywords:
Pubs id:
pubs:809047
UUID:
uuid:0e83c18c-cd5c-4dff-b3a4-3faf463ce189
Local pid:
pubs:809047
Deposit date:
2017-12-11

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