Thesis
A functional and structural study of HLA-B*2705 restricted CTL responses associated with delayed HIV-1 disease progression
- Abstract:
-
The HIV-1 Gag p24 protein contains the HLA class-1 B*2705 restricted epitope KK10, responses to which are associated with delayed progression. Data from in vitro proteasomal digestion studies from our group has shown the production of a number of C-terminally extended and truncated epitopes containing KK10, produced in far higher quantities during proteasomal digestion than this “optimal epitope” and that the amount of antigen made in proteasomal digestion is instrumental in deter...
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Authors
Contributors
+ Iversen, A
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
+ Fugger, L
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:0edd1e9a-e356-45b1-8e31-a4f29e199408
- Local pid:
- ora:8558
- Deposit date:
- 2014-06-10
Terms of use
- Copyright holder:
- Pymm, P
- Copyright date:
- 2012
- Notes:
- This thesis is not currently available via ORA.
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