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High resolution AMS imaging of radiocarbon in biomedical applications

Abstract:

Radiocarbon has been an important labelling element in biological metabolism studies. By interfacing an accelerator mass spectrometer (AMS) with a scanning microprobe secondary ion source, we have imaged the uptake of radiocarbon labelled metabolic or neurotransmitter amino acids by neurons and glial cells of rats and gerbils at high resolution (1 micron), high sensitivity and in a short time. The biological samples are prepared and sectioned serially at 0.5 mu m thickness using standard hist...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Oxford, Radiocarbon Accelerator Unit
Role:
Author
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Institution:
University of Oxford
Division:
HUMS
Department:
History Faculty
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, Radiocarbon Accelerator Unit
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms Journal website
Volume:
123
Issue:
1-4
Pages:
271-274
Publication date:
1997-03-01
Event title:
7th Conference on Accelerator Mass Spectrometry
DOI:
ISSN:
0168-583X
Source identifiers:
18329
UUID:
uuid:0ee98b74-3e42-412c-8c73-f6a34dbe16ad
Local pid:
pubs:18329
Deposit date:
2012-12-19

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