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Cilia-associated oxysterols activate Smoothened

Abstract:

Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we identify cilia-associated oxysterols that promote Smoothened accumulation in cilia and activate the Hedgehog pathway. Our data reveal that cilia-associated oxysterols bind to two distinct Smoothened domains to modulate Smoothened accumulation in cilia and tune the intensity of Hedgehog pathway activation. We find that...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Cell Press Publisher's website
Journal:
Molecular Cell Journal website
Volume:
72
Issue:
2
Pages:
316-327.e5
Publication date:
2018-10-18
Acceptance date:
2018-08-21
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Pmid:
30340023
Source identifiers:
926971
Language:
English
Keywords:
Pubs id:
pubs:926971
UUID:
uuid:0ef47423-40ad-4118-a563-4b5c1d3abe19
Local pid:
pubs:926971
Deposit date:
2019-10-07

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