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Imaging DNA damage in vivo using gammaH2AX-targeted immunoconjugates.

Abstract:

DNA damage responses (DDR) occur during oncogenesis and therapeutic responses to DNA damaging cytotoxic drugs. Thus, a real-time method to image DNA damage in vivo would be useful to diagnose cancer and monitor its treatment. Toward this end, we have developed fluorophore- and radioisotope-labeled immunoconjugates to target a DDR signaling protein, phosphorylated histone H2A variant H2AX (γH2AX), which forms foci at sites of DNA double-strand breaks. Anti-γH2AX antibodies were modified by the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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CR-UK/EPSRC/MRC/NIHR Oxford Cancer Imaging Centre More from this funder
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Cancer Research UK More from this funder
Publisher:
American Association for Cancer Researc Publisher's website
Journal:
Cancer research Journal website
Volume:
71
Issue:
13
Pages:
4539-4549
Publication date:
2011-01-01
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Source identifiers:
140871

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