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Paradoxical prolongation of QT interval during exercise in patients with HCM: Cellular mechanisms and implications for diastolic function

Abstract:

Aims Ventricular cardiomyocytes from Hypertrophic Cardiomyopathy (HCM) patient hearts show prolonged action potential duration (APD), impaired intracellular Ca2+ homeostasis and abnormal electrical response to beta -adrenergic stimulation. We sought to determine whether this behavior is associated with abnormal changes of repolarization during exercise and worsening of diastolic function, ultimately explaining the intolerance to exercise experienced by some patients without obstruction. Meth...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/ehjopen/oeac034

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Role:
Author
ORCID:
0000-0002-4096-3173
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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
European Heart Journal Open Journal website
Article number:
oeac034
Publication date:
2022-05-10
Acceptance date:
2022-04-14
DOI:
EISSN:
2752-4191
Language:
English
Keywords:
Pubs id:
1261264
Local pid:
pubs:1261264
Deposit date:
2022-05-27

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